Modified antibody fragments

Details Modified antibody fragments Modified antibody fragments

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2527866

The present invention relates to a new class of antibody fragments including antibody Fab and Fab' fragments in which the heavy chain is not covalently bonded to the light chain and two or more effector molecules are attached to the fragment, of which at least one of said molecules is attached to a cysteine in the heavy or light chain constant region.

Cette invention se rapporte à une nouvelle classe de fragments d'anticorps contenant les fragments d'anticorps Fab et Fab', dont la chaîne lourde n'est pas liée de façon covalente à la chaîne légère et dont au moins deux molécules effectrices sont fixées au fragment, au moins l'une de ces deux molécules étant fixée à une cystéine dans la région constante de la chaîne lourde ou de la chaîne légère.

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