Modified antigen-presenting cells

Details Modified antigen-presenting cells Modified antigen-presenting cells

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 35/12 (2006.01) A61P 37/02 (2006.01) C07K 14/74 (2006.01) C12N 5/06 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2467893

The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-presenting cells of the invention will provide a therapeutic strategy of modulating immune responses for a variety of diseases.

La présente invention a trait à des cellules présentatrices d'antigène présentant une spécificité contre un antigène sélectionné et des procédés permettant la fabrication de telles cellules. L'invention a trait également à un procédé de sélection de cellules présentatrices d'antigène efficaces utilisant des constructions de fusion de gènes rapporteurs. Les cellules présentatrices d'antigène à efficacité élevée de l'invention fournissent un stratégie thérapeutique de modulation de réponses immunitaires pour une variété de maladies.

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