Modified antigen-presenting cells

Details Modified antigen-presenting cells Modified antigen-presenting cells

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01) A61K 39/00 (2006.01) A61K 39/38 (2006.01) C12N 5/02 (2006.01)

Patent

CA 2566903

The invention relates to antigen-presenting cells having specificity against a selected antigen and methods for making the cells. The invention also relates to a method of selecting efficient antigen-presenting cells using reporter fusion constructs. The highly efficient antigen-presenting cells of the invention will provide a therapeutic strategy of modulating immune responses for a variety of diseases.

L'invention concerne des cellules de présentation de l'antigène présentant une spécificité contre un antigène sélectionné ainsi que des méthodes d'obtention desdites cellules. L'invention concerne également un procédé de sélection de cellules de présentation efficace de l'antigène faisant appel à des constructions de fusion de gènes rapporteurs. Les cellules de présentation hautement efficace de l'antigène selon l'invention permettent d'obtenir une stratégie thérapeutique de modulation de réponses immunitaires pour une variété de maladies.

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