C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/57 (2006.01) C12N 9/50 (2006.01) C12N 9/64 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2477243
The present invention relates to recombinant human BACE polypeptides. More particularly, the invention relates to recombinant human BACE polypeptides that have a modified amino acid sequence at position 33 of the BACE sequence, as well as to polynucleotides, expression vectors, host cells, and methods for producing the modified recombinant human BACE polypeptides.
La présente invention concerne des polypeptides humains recombinants de l'enzyme de clivage du site .beta. de l'APP (BACE). Notamment, cette invention a trait à des polypeptides humains recombinants de l'enzyme BACE qui ont une séquence d'acides aminés modifiée à la position 33 de la séquence de l'enzyme BACE, ainsi qu'à des polynucléotides, à des vecteurs d'expression, à des cellules hôtes, et à des méthodes de production des polypeptides humains recombinants de l'enzyme BACE.
Chou Kuo-Chen
Howe W. Jeffrey
Elan Pharmaceuticals Inc.
Osler Hoskin & Harcourt Llp
Pharmacia & Upjohn Company
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