Modified bacteriocins and methods for their use

Details Modified bacteriocins and methods for their use Modified bacteriocins and methods for their use

C - Chemistry, Metallurgy

07

K

C07K 14/21 (2006.01)

Patent

CA 2652450

Modified forms of naturally occurring bacteriocins, such as the R-type pyocins of Pseudomonas aeruginosa, are disclosed. The bacteriocins are modified at the ends of their tail fibers in a region responsible for binding specificity and affinity to their cognate binding partners, or receptors, such as those on the surface of bacteria. Methods for the use of the modified bacteriocins, such as to bind receptors, including virulence or fitness factors, on the surfaces of bacteria, are also described.

La présente invention concerne des formes modifiées de bactériocines naturelles, telles que les pyocines de type R de Pseudomonas aeruginosa. Les bactériocines sont modifiées aux extrémités de leurs fibres caudales dans une région responsable de la spécificité de liaison et de l'affinité vis-à-vis de leurs partenaires de liaison apparentés, ou récepteurs, tels que ceux se trouvant à la surface des bactéries. La présente invention concerne également des procédés d'utilisation des bactériocines modifiées, telles que la liaison avec les récepteurs, y compris les facteurs de virulence ou de valeur sélective, à la surface des bactéries.

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