Modified bacteriophage including an alpha/beta small...

C - Chemistry – Metallurgy – 12 – N

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C12N 7/00 (2006.01) A01N 63/00 (2006.01) A61K 35/76 (2006.01)

Patent

CA 2695939

Provided is a modified bacteriophage capable of infecting a target bacterium, which bacteriophage includes an .alpha./.beta. small acid-soluble spore protein (SASP) gene encoding a SASP which is toxic to the target bacterium, wherein the SASP gene is under the control of a constitutive promoter which is foreign to the bacteriophage and the SASP gene.

La présente invention concerne un bactériophage modifié capable d'infecter une bactérie cible, ledit bactériophage comprenant le gène d'une petite protéine sporale acido-soluble (SASP) a/ß encodant une SASP qui est toxique pour la bactérie cible, le gène SASP étant sous le contrôle d'un promoteur constitutif étranger au bactériophage et au gène SASP.

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