Modified biodegradable polymers, preparation and use thereof...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/78 (2006.01) A61K 8/73 (2006.01) A61K 31/722 (2006.01) A61K 38/39 (2006.01) A61L 15/28 (2006.01) A61L 15/32 (2006.01) C08B 37/00 (2006.01) C08B 37/08 (2006.01)

Patent

CA 2620633

The invention concerns a method for preparing in aqueous medium a modified biodegradable polymer comprising at least two steps. The first step is a step of reaction between an amino acid, a peptide or a polypeptide and maleic anhydride to form a compound having an unsaturated vinyl-carboxylic acid function. In the second reaction step, the unsaturated diacid obtained in the first step is reacted with a biodegradable polymer having at least one primary amine function, such as a fibrous protein or a glycosaminoglycan. The preferred polymer used is collagen or chitosan. The invention also concerns the modified biodegradable polymer obtained by said method. The invention further concerns a biomaterial or a dressing containing the modified biodegradable polymer having biocompatible, cytocompatible, hemostatic, bactericidal and wound-healing properties, and its medical, biomedical, pharmaceutical or cosmetic use.

L'invention concerne un procédé de préparation en milieu aqueux d'un polymère biodégradable modifié comprenant au moins deux étapes. La première de celles- ci est une étape de réaction entre un aminoacide, un peptide ou un polypeptide et I'anhydride maléique pour former un composé ayant une fonction acide vinyl- carboxylique insature. Dans la seconde étape de réaction, le diacide insature obtenu a la première étape est mis en réaction avec un polymère biodégradable ayant au moins une fonction amine primaire, tel une protéine fibreuse ou un glycosaminoglycane. Le polymère préférentiellement utilisé est du collagène ou du chitosane. L'invention concerne également le polymère biodégradable modifié obtenu avec ce procédé. L'invention concerne de plus un biomatériau ou un pansement contenant le polymère biodégradable modifié ayant des propriétés biocompatibles, cyto-compatibles, hémostatiques, bactéricides et cicatrisantes, et son usage médical, biomédical, pharmaceutique ou cosmétique.

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