C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2324870
A graftable animal cell or tissue of a donor species for use in medicine expresses, or is capable of being caused to express, increased amounts of endogenous complement regulatory molecules for preventing activation of complement in a recipient species. Such tissue or organs are useful for xenotransplantation. Porcine complement regulatory proteins CD59, DAF have been sequenced. Also disclosed are methods of inducing in an animal cell or tissue resistance protection against complement attack.
L'invention porte sur des cellules ou tissus animaux greffables d'espèces donneuses, à usage médical, exprimant ou pouvant être amenés à exprimer des quantités accrues de molécules porcines DAF CD59 régulatrice du complément endogène empêchant l'activation du complément dans les espèces réceptrices. Lesdits tissus ou organes servent à des xénotransplantations. L'invention porte également sur le séquençage de protéines porcines DAF CD59, et sur des méthodes suscitant dans une cellule ou un tissu animal une protection résistant aux attaques du complément.
Hinchliffe Stewart James
Morgan Bryan Paul
Rushmere Neil Kevin
Van Den Berg Carmen Wilma
Mcfadden Fincham
University College Cardiff Consultants Limited
University Of Wales College Of Medicine
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