C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/37 (2006.01) A61K 48/00 (2006.01) C07K 14/755 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/67 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2396616
A modified factor VIII cDNA is disclosed, wherein in introns 1 and/or 13 of the wild- type factor VIII cDNA one or more splicable nucleotide sequences or a nucleotide sequence which will be spliced during the export of the pre-mRNA from the nucleus have been inserted. Further a process for the production of a biologically active recombinant human factor VIII or its derivative is disclosed, which is performed by cultivating an animal cell fine comprising a recombinant expression vector containing said modified factor VIII cDNA. Moreover a transfer vector for use in the human gene therapy is described which comprises said modified factor VIII cDNA.
Hauser Hans-Peter
Negrier Claude
Plantier Jean-Luc
Rodriguez Marie-Helene
Aventis Behring Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Zlb Behring Gmbh
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