Modified cea and uses thereof

Details Modified cea and uses thereof Modified cea and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 7/01 (2006.01) C12N 15/86 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2416893

The invention discloses immunogenic CEA agonist polypeptides/proteins comprising a modified epitope containing the amino acid sequence YLSGADLNL, nucleic acids coding therefor, vectors and/or cells comprising said nucleic acids, and mixtures and/or compositions thereof. Methods for eliciting or inducing CEA-specific immune responses utilizing the aforementioned agents are also disclosed.

La présente invention concerne, d'une part des polypeptides ou protéines agonistes de l'antigène CEA (Carcinoembryonic Antigen) immunogènes comprenant un épitope modifié contenant la séquence d'acide aminé YLSGADLNL, d'autre part des acides nucléiques codant pour eux, mais aussi des vecteurs et/ou cellules comprenant ces acides nucléiques, et enfin des mélanges et/ou compositions les intégrant. L'invention concerne également des procédés permettant de susciter ou d'induire des réponses immunitaires spécifiques du CEA par utilisation de ces agents.

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