C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/18 (2006.01) C07K 14/475 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2439682
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of human ciliary neutrophic factor (CNTF) to result in CNTF proteins that are substantially non-imminogenic or less immunogenic than any non-modified counterpart when used in vivo.
La présente invention concerne des polypeptides destinés à être administrés notamment aux humains et en particulier pour usage thérapeutique. Les polypeptides sont des polypeptides modifiés dont la modification entraîne une tendance réduite du polypeptide à déclencher une réponse immunitaire lorsqu'il est administré à un sujet humain. L'invention concerne notamment la modification du facteur CNTF humain en vue d'obtenir des protéines du facteur CNTF qui soient sensiblement non immunogènes ou moins immunogènes que tout homologue non modifié lors de son utilisation in vivo.
Carr Francis J.
Carter Graham
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschrankter Haftung
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