C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) C12N 1/21 (2006.01) C12N 15/00 (2006.01) C12N 15/74 (2006.01) C12P 7/10 (2006.01)
Patent
CA 2759245
Bacteria consume a variety of biomass-derived substrates and produce ethanol. The scaffoldin gene cipA from Clostridium thermocellum is modified to generate a mutated gene with enhanced genetic stability. This mutated cipA gene can be introduced into a heterologous host, such as Thermoanaerobacterium saccharolyticum. Other cellulosome components may be introduced into the host to build a full-sized cellulosome in T. saccharolyticum. Manipulation of the scaffoldin genes provides a new approach for enhancing ethanol production by biomass-fermenting microorganisms.
L'invention concerne la modification du gène cipA d'armature de Clostridium thermocellum pour générer un gène muté ayant une meilleure stabilité génétique. Ce gène cipA muté peut être introduit dans un hôte hétérologue, comme Thermoanaerobacterium saccharolyticum. D'autres composants de cellulosome peuvent être introduits dans l'hôte pour construire un cellulosome pleine longueur dans T. saccharolyticum. Certaines bactéries consommant divers substrats dérivés de la biomasse et produisant de l'éthanol, la manipulation des gènes d'armature est une nouvelle approche pour améliorer leur production d'éthanol par fermentation de la biomasse.
Currie Devin Hedley
Guss Adam
Mcbride John
Smart & Biggar
The Trustees Of Dartmouth College
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