C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/33 (2006.01) C12N 9/52 (2006.01) C12N 15/09 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2428136
The present invention discloses modified neurotoxins with altered biological persistence. In one embodiment, the modified neurotoxins are derived from Clostridial botulinum toxins and the modification involves one or more secondary modification sites. In a BoNT/E (Botilunum Toxin serotype E) derivative, the N-terminal myristylation site GVDIAY is fused to position 15 of the BoNT/E light chain. In a BoNT/A derivative the N-terminal myristylation site GLEVSF at position 254 is deleted. Such modified neurotoxins may be employed in treating various conditions, including but not limited to muscular disorders, hiperhidrosis, and pain.
La présente invention concerne des neurotoxines modifiées présentant une persistance biologique altérée. Dans un mode de réalisation, ces neurotoxines sont dérivées de toxines de Clostridium botulinum. Lesdites neurotoxines modifiées peuvent être utilisées dans le traitement de divers états pathologiques, tels que les troubles musculaires, l'hyperhidrose et la douleur, entre autres.
Aoki Kei Roger
Lin Wei-Jen
Spanoyannis Athena
Steward Lance E.
Allergan Inc.
Gowling Lafleur Henderson Llp
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