Modified cytochrome p450 monooxygenases

Details Modified cytochrome p450 monooxygenases Modified cytochrome p450 monooxygenases

C - Chemistry, Metallurgy

12

N

C12N 15/53 (2006.01) C12N 1/21 (2006.01) C12N 9/02 (2006.01) C12N 15/70 (2006.01) C12P 7/02 (2006.01) C12P 7/04 (2006.01) C12P 7/22 (2006.01) C12P 7/42 (2006.01) C12P 7/64 (2006.01) C12P 17/10 (2006.01) C12P 17/16 (2006.01) C12Q 1/26 (2006.01)

Patent

CA 2378615

The invention relates to modified cytochrome P450 monooxygenases comprising a modified substrate profile, to nucleic acid sequences that code therefor, to expression constructs and vectors, and to recombinant microorganisms which contain these vectors. The invention also relates to methods for microbiologically producing terminally or subterminally hydroxylated aliphatic carboxylic acids.

La présente invention concerne des monooxygénases à cytochrome P450 modifiées à profil de substrat modifié, des séquences d'acide nucléique, des structures d'expression et des vecteurs codant pour ces monooxygénases, des micro-organismes recombinés comprenant ces vecteurs, ainsi des procédés de préparation microbiologique d'acides carboxyliques aliphatiques à groupes hydroxyle terminaux ou subterminaux.

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