Modified cytokines for therapeutic use

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/525 (2006.01) A61K 38/19 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C07K 19/00 (2006.01)

Patent

CA 2247308

The object of the present invention is a new method and new products for the therapeutic use of cytokines. The method is based on the sequential administration of a component A (e.g. a biotinylated antibody) able to deliver onto a particular pathologic target a second component B (e.g. avidin), followed by a component able to bind the component B (component C) (e.g. biotin), conjugated with the cytokines. The method permits to increase the local concentration of the modified cytokines (C-cytokines) through the interaction with the "artificial" receptor B and to cause a local biologic response mediated by "natural" receptors.

L'invention concerne une nouvelle méthode d'utilisation thérapeutique des cytokines et de nouveaux produits pour la mise en oeuvre de cette méthode. La méthode est basée sur l'administration séquentielle d'un composant A (par exemple un antibiotique biotinylé) capable d'amener, vers une cible particulière atteinte d'une pathologie, un second composant B (par exemple de l'avidine), suivie par celle d'un composant capable de se lier au composant B comme par exemple la biotine (composant C), conjugué avec les cytokines. Le procédé permet d'augmenter la concentration locale en cytokines modifiées (cytokines C) par l'interaction avec le récepteur "artificiel" B et de provoquer une réponse biologique locale assurée par les récepteurs "naturels".

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