Modified dendritic cells

Details Modified dendritic cells Modified dendritic cells

A - Human Necessities

61

K

A61K 48/00 (2006.01) C12N 15/11 (2006.01) C12N 15/74 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2505403

Infection of a dendritic cell with a lentivirus impairs the dendritic cell's ability to act as an antigen presenting cell that polarizes a naïve T cell to develop along the Th1 pathway. This impairment is restored by infecting dendritic cells with lentiviruses containing vectors encoding IL-7, IL-12, and siRNA targeting IL-10 RNA.

L'infection d'une cellule dendritique avec un lentivirus altère l'aptitude de la cellule dendritique à agir comme une cellule présentant un antigène qui polarise un lymphocyte T naïf pour qu'il se développe le long du chemin du Th1. On remédie à cette altération en infectant les cellules dendritiques avec des lentivirus contenant des vecteurs codant l'IL-7, l'IL-12, et l'ARNsi ciblant l'ARN à IL-10.

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