Modified derivatives of cck-8

Details Modified derivatives of cck-8 Modified derivatives of cck-8

C - Chemistry, Metallurgy

07

K

C07K 14/595 (2006.01) A61K 38/22 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2439598

The invention provides a peptide based on biologically active CCK-8 having improved characteristics for the treatment of obesity and/or type 2 diabetes wherein the primary structure of CCK-8 is: Asp1Tyr2(SO3H)- Met3Gly4Trp5Met6Asp7Phe8amide and wherein the peptide has at least one amino acid substitution and/or modification and is not Asp1-glucitol CCK-8. The invention also provides the use of the peptide in the preparation of a medicament to inhibit food intake, induce satiety, stimulate insulin secretion, moderate blood glucose exursions, enhance glucose disposal and/or exhibit enhanced stability in plasma compared to native CCK-8 and/or for treatment of obesity and/or type 2 diabetes.

L'invention concerne un peptide à base de CCK-8 biologiquement active, ce peptide présentant des caractéristiques améliorées pour le traitement de l'obésité et/ou du diabète de type 2. La structure primaire de la CCK-8 est : Asp?1¿Tyr?2¿(SO¿3?H)-Met?3¿Gly?4¿Trp?5¿Met?6¿Asp?7¿Phe?8¿amide. Le peptide comprend au moins une substitution et/ou une modification d'acides aminés et n'est pas Asp?1¿-glucitol CCK-8. L'invention concerne également l'utilisation du peptide dans la préparation d'un médicament afin d'inhiber l'absorption de nourriture, d'induire la satiété, de stimuler la sécrétion d'insuline, de modérer les excursions glycémiques, d'améliorer l'élimination de glucose et/ou de présenter une stabilité renforcée dans le plasma comparé à la CCK-8 native et/ou pour le traitement de l'obésité et/ou du diabète de type 2.

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