Modified dhps genes

Details Modified dhps genes Modified dhps genes

C - Chemistry, Metallurgy

12

N

C12N 15/82 (2006.01) A01H 5/00 (2006.01) A23K 1/14 (2006.01) A23K 1/16 (2006.01) C12N 5/04 (2006.01) C12N 9/88 (2006.01)

Patent

CA 2395529

The invention relates to modifications of biosynthesis key enzymes leading to essential amino acid accumulation in cells. A recombinant or isolated nucleic acid, or functional fragment thereof, encoding an enzyme dihydrodipicolinate synthase (DHPS), or functional fragment thereof, having been provided with a mutation leading to the replacement of at least one single amino acid residue with a cysteine residue.

L'invention concerne des modifications d'enzymes clés de biosynthèse conduisant à l'accumulation d'acides aminés essentiels dans des cellules. Un acide nucléique recombiné ou isolé, ou un fragment fonctionnel de celui-ci, codant l'enzyme dihydrodipicolinate synthase (DHPS), ou un fragment fonctionnel de celle-ci, a reçu une mutation conduisant au remplacement d'au moins un seul reste d'acide aminé par un reste de cystéine.

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