Modified endolysin ply511

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 9/50 (2006.01) C12N 1/04 (2006.01)

Patent

CA 2724070

The present invention relates to polypeptides with a changed amino acid sequence on at least one amino acid position compared to the amino acid sequence according to SEQ ID NO: 1. The present invention further relates to the nucleotide sequences encoding the polypeptide, vectors, comprising the nucleotide sequences and host cells for expression of the polypeptide. The present invention further relates to the use of the polypeptides as a human, veterinary medical or diagnostic substance, in food, in cosmetics, as disinfectant or in the environmental field.

La présente invention concerne des polypeptides ayant une séquence dacides aminés modifiée en au moins une position dacide aminé en comparaison de la séquence dacides aminés selon la SEQ ID NO: 1. La présente invention concerne également les séquences nucléotidiques qui codent pour le polypeptide, des vecteurs qui comprennent les séquences nucléotidiques et des cellules hôtes pour lexpression du polypeptide. La présente invention concerne également lutilisation des polypeptides en tant que substance diagnostique ou médicale humaine ou vétérinaire, dans les produits alimentaires, dans les produits cosmétiques, en tant que désinfectant ou dans le domaine environnemental.

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