C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/04 (2006.01) A61K 31/35 (2006.01) A61K 31/70 (2006.01) C07H 15/14 (2006.01)
Patent
CA 2233168
This invention provides lipids having: 1) a glycerol backbone; 2) a hydrocarbon chain, preferably saturated and containing 16 or 18 carbon atoms, attached to C-1 of the backbone by an ether linkage; 3) a methyl group attached to C-2 of the backbone, preferably by an ether linkage; and, 4) a sugar attached to C-3 of the glycerol backbone in either the alpha or beta anomeric configuration, the sugar being altered by modification of, or substitution for, one or more of its hydroxyl groups. Also provided herein are ether-lipid-containing compositions, as well as methods of administering such compositions to animals, for example, those afflicted with cancers, as well as various other diseases and disorders.
L'invention porte sur des lipides comprenant: 1) un squelette glycérol; 2) une chaîne hydrocarbure, de préférence saturée, contenant 16 ou 18 atomes de carbone, fixée au C-1 du squelette par une liaison éther; 3) un groupe méthyle fixé au C-2 du squelette de préférence par une liaison éther; et 4) un sucre fixé au C-3 du squelette glycérol en configuration anomérique alpha ou bêta, le sucre étant changé par modification ou substitution d'un ou plusieurs de ses groupes hydroxyle. L'invention concerne également des compositions contenant des éthers-lipides, et des procédés d'administration de ces compositions à des animaux, par exemple, atteints de cancers ou d'autres pathologies ou troubles.
Bittman Robert
Erukulla Ravi K.
Mayhew Eric G.
Peters Andrew C.
Osler Hoskin & Harcourt Llp
The Liposome Company Inc.
The Research Foundation Of The City University Of New York
Zeneus Pharma Limited
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