Modified exendins and uses thereof

Details Modified exendins and uses thereof Modified exendins and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2603630

Novel exendins with modifications at one or more of following positions: 2, 14, 27 or 28 and polyethylene glycol derivatives thereof are provided. These modified exendins are useful in treating type 2 diabetes as GLP-1 receptor agonists.

Cette invention concerne de nouvelles exendines comportant des modifications au niveau d'une ou plusieurs des positions suivantes : 2, 14, 27 ou 28, et des dérivés polyéthylène glycol de ces exendines. Ces exendines modifiées sont utiles comme agonistes du récepteur GLP-1 pour traiter le diabète non insulino-dépendant.

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