Modified exosomes and uses

Details Modified exosomes and uses Modified exosomes and uses

C - Chemistry, Metallurgy

12

N

C12N 5/10 (2006.01) A61K 39/385 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/12 (2006.01) G01N 33/50 (2006.01) G01N 33/543 (2006.01) G01N 33/554 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2349679

The invention concerns the fields of biology and immunology. It concerns membrane vesicles comprising molecules, in particular antigenic molecules, with predetermined structure, and their uses, More particularly, it concerns vesicles (exosomes) comprising recombinant molecules of the major histocompatibility complex, and their use as immunogen or for diagnostic and therapeutic purposes. The invention also concerns methods for producing said vesicles, genetic constructs, cells and compositions, useful for implementing said methods.

La présente invention concerne les domaines de la biologie et de l'immunologie. Elle est relative à des vésicules membranaires comportant des molécules, notamment antigéniques, de structure prédéterminée, et à leurs utilisations. Elle concerne plus particulièrement des vésicules (exosomes) comportant des molécules recombinantes du complexe majeur d'histocompatibilité, et leur utilisation comme immunogène ou comme outil diagnostique ou thérapeutique. L'invention est également relative à des méthodes de production de ces vésicules, des constructions génétiques, cellules et compositions, utilisables pour la mise en oeuvre des méthodes de l'invention.

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