Modified factor ix polypeptides and uses thereof

Details Modified factor ix polypeptides and uses thereof Modified factor ix polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) C12N 15/57 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2721683

Disclosed are modified Factor IX polypeptides such as Factor IX polypeptides with one or more introduced glycosylation sites. The modified Factor IX polypeptides may exhibit increased in vitro or in vivo stability such as a longer plasma half- life. Also, methods are disclosed of making modified Factor IX polypeptides, and methods of using modified Factor IX polypeptides, for example, to treat patients afflicted with hemophilia B.

La présente invention concerne des polypeptides modifiés de facteur IX tels que des polypeptides de facteur IX avec un ou des sites de glycosylation introduits. Les polypeptides modifiés de facteur IX peuvent présenter une stabilité accrue in vitro ou in vivo telle quune demi-vie plasmatique plus longue. Linvention concerne également des procédés de fabrication de polypeptides modifiés de facteur IX, et des procédés dutilisation de polypeptides modifiés de facteur IX, par exemple, pour traiter des patients atteints de lhémophilie B.

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