A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 38/16 (2006.01) A61K 38/49 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2203280
The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modification render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.
Le site actif catalytique du facteur VII est modifié pour produire un composé qui interrompt efficacement la cascade des réactions de coagulation du sang. La modification rend le facteur VIIa pratiquement incapable d'activer les facteurs X ou IX plasmatiques. Des compositions pharmaceutiques du facteur VII modifié sont utilisées pour traiter divers troubles liés à la coagulation.
Berkner Kathleen L.
Bregengaard Claus
Hart Charles E.
Hedner Ulla
Petersen Lars Christian
Gowling Lafleur Henderson Llp
Novo Nordisk A/s
Novo Nordisk Health Care Ag
Zymogenetics Inc.
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