Modified factor vii

Details Modified factor vii Modified factor vii

A - Human Necessities

61

K

A61K 38/48 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2162726

The catalytic active site of Factor VII is modified to produce a compound which effectively interrupts the blood coagulation cascade. The modification render Factor VIIa substantially unable to activate plasma Factors X or IX. Pharmaceutical compositions of the modified Factor VII are used to treat a variety of coagulation-related disorders.

On a modifié le site catalytique actif du facteur VII afin qu'il produise un composé interrompant efficacement la série des réactions en cascade dans la coagulation sanguine. Les modifications rendent le facteur VIIa incapable d'activer les facteurs X ou IX du plasma. On utilise des compositions pharmaceutiques à base du facteur VII modifié afin de traiter divers troubles liés à la coagulation.

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