Modified factor vii polypeptides and uses thereof

Details Modified factor vii polypeptides and uses thereof Modified factor vii polypeptides and uses thereof

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) C07K 14/745 (2006.01)

Patent

CA 2683443

Modified factor VII polypeptides and uses thereof are provided. Such modified FVII polypeptides include Factor Vila and other forms of Factor VII. Among modified FVII polypeptides provided are those that have altered activities, typically altered procoagulant activity, including increased procoagulant activities. Hence, such modified polypeptides are therapeutics.

Cette invention se rapporte à des polypeptides du facteur VII modifiés et à leurs utilisations. Lesdits polypeptides du facteur FVII modifiés comprennent le facteur VIIa et d'autres formes du facteur VII. Parmi les polypeptides du facteur FVII modifiés figurent les polypeptides dont les activités sont modifiées, typiquement une activité procoagulante modifiée, y compris des activités procoagulantes accrues. Ces polypeptides modifiés sont donc des agents thérapeutiques.

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