Modified factor viii

Details Modified factor viii Modified factor viii

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/14 (2006.01) A61K 38/37 (2006.01) A61P 7/04 (2006.01) C07K 14/755 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2374675

Specific amino acid loci of human factor VIII interact with inhibitory antibodies of hemophilia patients who have developed such antibodies after being treated with factor VIII. Modified factor VIII is disclosed in which the amino acid sequence is changed by a substitution at one or more amino acids of positions 484-508 of the A2 domain. The modified factor VIII is useful as a clotting factor supplement for hemophiliacs.

Les loci d'acides aminés spécifiques du facteur VIII humain interagissent avec des anticorps inhibiteurs de patients hémophiles qui ont produit de tels anticorps après avoir été traités avec le facteur VIII. L'invention se rapporte à un facteur VIII modifié dans lequel on a modifié la séquence d'acides aminés en substituant un ou plusieurs acides aminés en positions 484 à 508 du domaine A2. Un tel facteur VIII modifié s'avère utile en tant que supplément du facteur de coagulation chez les sujets hémophiles.

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