C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/37 (2006.01) A61K 48/00 (2006.01) C07K 14/755 (2006.01)
Patent
CA 2300782
A modified Factor VIII cDNA is described in which the B-domain of the wild- type Factor VIII cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in one or more locatons of the Factor VIII cDNA. Such modified Factor VIII cDNA may be used for a higher yield production of Factor VIII in vitro as well as in a transfervector for gene therapy.
Negrier Claude
Plantier Jean Luc
Aventis Behring Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Zlb Behring Gmbh
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