Modified factor viii cdna and its use for the production of...

Details Modified factor viii cdna and its use for the production of... Modified factor viii cdna and its use for the production of...

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) C07K 14/755 (2006.01) C12N 9/64 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2371447

A modified Factor VIII cDNA is disclosed wherein the B-domain of the wild type factor cDNA has been deleted and a truncated Factor IX intron 1 has been inserted in two locations of the Factor VIII cDNA and as a promoter a cDNA is used which is suitable for the expression in hematopoietic cell lines and specifically in platelets.

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