Modified fiber proteins for efficient receptor binding

Details Modified fiber proteins for efficient receptor binding Modified fiber proteins for efficient receptor binding

C - Chemistry, Metallurgy

12

N

C12N 15/861 (2006.01) A61K 48/00 (2006.01) C07K 14/075 (2006.01) C12N 15/34 (2006.01)

Patent

CA 2527954

Recombinant detargeted and retargeted adenovirus viral particles and vectors are provided. In particular, modified fibers from adenoviruses that bind to coxsackie-adenovirus receptor (CAR) in vivo that contain modifications in the fiber shaft are provided. Adenovirus (Ad) particles that express such fibers exhibit reduced binding to CAR. Hence detargeted Ad particles are provides; also provided are retargeted particles.

L'invention concerne des particules virales d'adénovirus reciblées et déciblées recombinées et des vecteurs associés. En particulier, l'invention concerne des fibres modifiées provenant d'adénovirus se liant au récepteur d'adénovirus coxsackie (CAR) <i>in vivo</i>, contenant des modifications dans la tige fibreuse. L'invention concerne des particules d'adénovirus (Ad) exprimant de telles fibres présentant une liaison réduite à CAR. Ainsi, l'invention concerne des particules Ad déciblées, ainsi que des particules reciblées.

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