Modified fluorinated nucleoside analogues

Details Modified fluorinated nucleoside analogues Modified fluorinated nucleoside analogues

C - Chemistry, Metallurgy

07

H

C07H 19/14 (2006.01) A61K 31/7064 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2734055

The disclosed invention relates to the use of antivirally effective amounts of (2'R)-2'- deoxy-2'-fluoro-2'-C-methyl nucleoside (.beta.-D or .beta.-L) for the preparation of a medicament for the treatment of Hepatitis C infection. (see above formula I) wherein the base is a pyrrolopyrimidine base represented by the following formula: (see formula II) R1 is independently H, monophosphate, a diphosphate, a triphosphate, a H- phosphonate, alkyl, an alkyl sulfonyl, or an arylalkyl sulfonyl; R4 is H, OH, NH2, NHR", NR"2, OR", SR", Cl, Br, or I; R" is a linear or branched alkyl, alkenyl, alkynyl, cycloalkyl, or -CH2CF3; and R5 is H, NH2, or Cl.

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