Modified fluorinated nucleoside analogues

Details Modified fluorinated nucleoside analogues Modified fluorinated nucleoside analogues

A - Human Necessities

61

K

A61K 31/7068 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2734066

The disclosed invention provides a method of inhibiting the proliferation of a Flaviviridae virus in a host, comprising penetrating a cell infected with the virus with an antivirally effective amount of a (2'R)-2'-deoxy-2'-fluoro-2'-C-methyl nucleoside (.beta.-D or .beta.-L) or its pharmaceutically acceptable salt of the structure: (see formula I) wherein the Base is a pyrimidine base represented by the following formula: (see formula II) X is O; R1 and R7 are independently H, a monophosphate, a diphosphate, a triphosphate, a H-phosphonate, alkyl, an alkyl sulfonyl, or an arylalkyl sulfonyl; and R3 is H and R4 is NH2 or OH.

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