Modified fluorinated nucleoside analogues

Details Modified fluorinated nucleoside analogues Modified fluorinated nucleoside analogues

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/513 (2006.01) A61K 31/52 (2006.01) A61K 31/7068 (2006.01) A61K 31/7076 (2006.01) A61P 31/14 (2006.01) A61P 35/00 (2006.01) C07D 239/36 (2006.01) C07D 239/46 (2006.01) C07D 473/02 (2006.01) C07H 19/06 (2006.01)

Patent

CA 2476279

The invention is a compound, composition, use for and a method of treating Flaviviridae (Hepacivirus, Flavirius, Pestivirus) infections, including BVDV and HCV, or abnormal cellular proliferation, including malignant tumors, in a host including animals, and especially humans, using a .szlig.-D or .szlig.-L nucleoside of general formula (1) - (XX), or their pharmaceutically acceptable salt or prodrug thereof.

L'invention concerne un composé, une composition, leur utilisation et une méthode de traitement des infections par Flaviviridae (Hépacivirus, Flavivirus, Pestivirus), y compris BVDV et HCV, ou d'une prolifération cellulaire anormale, y compris les tumeurs malignes, chez un hôte, y compris chez les animaux et en particulier chez l'homme, à l'aide d'un nucléoside .szlig.-D ou .szlig.-L représenté par la formule générale (1) - (XX), ou d'un sel ou d'un promédicament acceptable d'un point de vue pharmaceutique de celui-ci.

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