C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A01K 67/027 (2006.01) A61K 31/713 (2006.01) C07H 21/00 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2494930
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double- stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.
La présente invention concerne un acide ribonucléique qui comprend une structure bicaténaire, ladite structure bicaténaire comportant un premier brin et un deuxième brin. Le premier brin comprend une première suite de nucléotides contigus et se trouve être au moins partiellement complémentaire à un acide nucléique cible, le deuxième brin comprend quant à lui une deuxième suite de nucléotides contigus et se trouve être au moins partiellement identique à un acide nucléique cible, ladite structure bicaténaire étant pourvue d'une extrémité franche.
Giese Klaus
Kaufmann Joerg
Klippel-Giese Anke
Atugen Ag
Borden Ladner Gervais Llp
Silence Therapeutics Ag
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