Modified forms of reproductive hormones

Details Modified forms of reproductive hormones Modified forms of reproductive hormones

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/24 (2006.01) C07K 14/59 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2053864

The invention provides recombinant native and mutant forms of human reproductive hormones with characteristic glycosylation patterns which are influential in the metabolic activity of the protein. The invention also provides recombinant mutant forms of the human alpha subunit common to FSH, LH, CG, and TSH, to obtain hormones which also have unique glycosylation patterns. Also provided are recombinant materials to produce these subunits separately or together to obtain complete heterodimeric hormones of regulated glycosylation pattern and activity. Modified forms of LH and FSH beta subunits which enhance the rate of dimerization and secretion of the dimers or individual chains are also disclosed.

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