Modified fungal cells and method for producing recombinant...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/54 (2006.01) C07H 21/04 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 9/10 (2006.01) C12N 15/80 (2006.01) C12N 15/81 (2006.01) C12P 21/00 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2140894

This invention relates to improved fungal cells and methods for producing recombinant products of improved quality and in high yields. More specifically, the present invention relates to fungal cells carrying specific modifications within their DNA sequences which cause them to exhibit at least a reduced capacity for O-glycosylating homologous and/or heterologous proteins, and the use of these cells as host cells to produce high yields of recombinant products.

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