Modified gene-silencing nucleic acid molecules and uses thereof

C - Chemistry – Metallurgy – 12 – N

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C12N 15/11 (2006.01)

Patent

CA 2568603

Methods and means for efficienty downregulating the expression of a target gene of interest in cell from an organism that is an animal, fungus and protist. The invention provides chimeric nucleic acid molecules for down regulating target genes. The invention also provides modified cells and organisms comprising the chimeric nucleic acid molecules and compositions comprising the chimeric molecules.

Méthodes et dispositifs servant à réguler négativement de façon efficace l'expression d'un gène ciblé dans une cellule provenant d'un organisme d'animal, de champignon ou de protiste. L'invention concerne des molécules d'acide nucléique chimères servant à réguler négativement ces gènes ciblés. Elle concerne également des cellules modifiées et des organismes comprenant ces molécules d'acide nucléique chimères, ainsi que des compositions contenant ces molécules chimères.

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