Modified gp100 and uses thereof

Details Modified gp100 and uses thereof Modified gp100 and uses thereof

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 35/76 (2006.01) A61K 39/275 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C12N 7/01 (2006.01) C12N 15/863 (2006.01) A61K 48/00 (2006.01) C07K 14/47 (2006.01)

Patent

CA 2388301

A gp100 molecule useful in modulating the immune system is described. In particular what is described is a nucleotide sequence for a gp100 which has been modified so as to be useful in modulating the immune system. The isolated nucleic acid sequence is described and referred to as gp100M. The corresponding protein, referred to as gp100M, is also described. Applications of the molecules as vaccines are described.

Cette invention, qui a trait à une molécule gp100, des plus utile s'agissant de moduler le système immunitaire, concerne, plus particulièrement, une séquence nucléotidique relative à une molécule gp100, laquelle molécule a été modifiée afin de la rendre utilisable aux fins de la modulation du système immunitaire. Cette séquence d'acide nucléique isolé décrite dans cette invention est dénommée gp100. La protéine correspondante, dénommée gp100, est également décrite. L'invention porte, de surcroît, sur les utilisations de ces molécules en tant que vaccins.

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