Modified guanidino and amidino thrombin inhibitors

Details Modified guanidino and amidino thrombin inhibitors Modified guanidino and amidino thrombin inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/06 (2006.01) A61K 31/395 (2006.01) A61K 38/04 (2006.01) C07D 207/09 (2006.01) C07D 211/60 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/02 (2006.01) C07K 5/062 (2006.01) C07K 5/065 (2006.01) C07K 5/068 (2006.01) C07K 5/072 (2006.01) C07K 5/078 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2151412

Thrombin inhibitors are provided which have the formula Image wherein Z is a thrombin inhibitor substructure containing distal and proximal binding site residues; and R1 is cyano, hydroxyl, alkoxy, amino, aminoalkyl or nitro.

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