C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 38/16 (2006.01) A61K 38/42 (2006.01) C07K 1/18 (2006.01) C07K 14/805 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2219242
The present invention relates to modified hemoglobin-like compounds. The novel compounds include a globin-like polypeptide containig at least two dialpha domains and multimeric hemoglobin-like proteins having a core hemoglobin-like moeity directly attached to at least two other hemoglobin-like moieties. The invention also relates to nucleic acid molecules encoding the novel polypeptides. Methods of making and purifying the multimeric hemoglobin-like proteins are also provided, as well as compositions containing the proteins.
La présente invention se rapporte à des composés modifiés analogues à l'hémoglobine. Ces nouveaux composés comprennent un polypeptide analogue à la globine contenant au moins deux domaines dialpha et des protéines multimères analogues à l'hémoglobine, possédant une fraction centrale analogue à l'hémoglobine directement liée à au moins deux autres fractions analogues à l'hémoglobine. L'invention se rapporte également à des molécules d'acide nucléique codant les nouveaux polypeptides. L'invention se rapporte également à des procédés de fabrication et de purification des protéines multimères analogues à l'hémoglobine ainsi qu'à des compositions contenant les protéines.
Anderson David C.
Anthony-Cahill Spencer
Epp Janet K.
Kerwin Bruce A.
Madril Dominic G.
Baxter Biotech Technology S.a.r.l.
Smart & Biggar
Somatogen Inc.
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