Modified hil-6

Details Modified hil-6 Modified hil-6

C - Chemistry, Metallurgy

07

K

530/13, 167/103.

C07K 14/54 (2006.01) A61K 38/20 (2006.01) A61K 47/48 (2006.01) C07K 17/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2036197

Disclosed are PEG-modified "interleukin-6" derivatives (PEG-IL-6) having an extended plasma half-life, as well as enhanced in vivo IL-6 biological activities. Methods for producing the modified glycosylated and unglycosylated IL-6 proteins or polypeptides, as well as, for their use in treating hematopoietic disorders and difficiencies, particularly acute thrombocytopenia, are also disclosed. The PEG is for example in the form of the formula: (see formula 1) (wherein n and m are each an integer of 7 to 600, and R1 and R2 are lower alkyl).

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