Modified hiv env polypeptides

Details Modified hiv env polypeptides Modified hiv env polypeptides

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) C07K 14/16 (2006.01) C07K 14/18 (2006.01) C12N 7/04 (2006.01) C12N 15/867 (2006.01) A61K 39/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2358915

Polynucleotide encoding modified HIV Env polypeptides are disclosed. The Env polypeptides are modified so as to expose at least part of the CD4 binding region. Methods of diagnosis, treatment and prevention using the polynucleotides and polypeptides are also provided.

Cette invention concerne des polynucléotides codant pour des polypeptides HIV Env modifiés. Cette modification des polypeptides Env permet d'exposer une partie au moins de la région de liaison CD4. L'invention concerne également des méthodes de diagnostic, de traitement et de prévention faisant intervenir lesdits polynucléotides et polypeptides.

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