Modified human c3 proteins

Details Modified human c3 proteins Modified human c3 proteins

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 38/48 (2006.01) A61K 47/48 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2197888

Native complement pathway proteins modified such that the protein is capable of forming a stable C3 convertase. Preferably the modified protein is a modified human C3 protein. DNA sequences encoding such proteins are also provided, together with DNA constructs. Conjugates comprising such proteins and a specific binding moiety, for example an antibody, are also described, as are uses of such proteins and/or conjugates in therapy.

L'invention se rapporte à des protéines natives, appartenant à un système complémentaire, qui sont modifiées de sorte que la protéine puisse former une convertase C3 stable. De préférence, la protéine modifiée est une protéine C3 humaine modifiée. Des séquences d'ADN codant ces protéines sont également décrites, ainsi que des produits de recombinaison d'ADN. Des conjugués comprenant ces protéines et une fraction de liaison spécifique, par exemple un anticorps, sont aussi décrits, ainsi que les utilisations thérapeutiques de ces protéines et/ou conjugués.

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