Modified human granulocyte-colony stimulating factor and...

Details Modified human granulocyte-colony stimulating factor and... Modified human granulocyte-colony stimulating factor and...

C - Chemistry, Metallurgy

12

N

C12N 15/70 (2006.01) C07K 14/535 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2378543

A modified human granulocyte-colony stimulating factor (hG-CSF) is produced by culturing a microorganism transformed with an expression vector comprising a gene encoding a modified hG-CSF to produce and secrete the modified hG-CSF to periplasm, said modified hG-CSF being obtained by replacing at least one of the 1st, 2nd, 3rd and 17th amino acids of wild-type hG-CSF (SEQ ID NO: 2) with other amino acid.

L'invention concerne un facteur stimulant les colonies de granulocytes humain modifié (hG-CSF), que l'on obtient en mettant en culture un micro-organisme transformé à l'aide d'un vecteur d'expression qui renferme un gène codant pour un facteur hG-CSF modifié, ce qui permet d'élaborer et de sécréter ce facteur hG-CSF modifié dans le périplasme. On élabore ce facteur hG-CSF modifié notamment en remplaçant au moins un des premier, deuxième, troisième et dix-septième aminoacides du facteur hG-CSF de phénotype sauvage (SEQ ID NO:2) par un autre aminoacide.

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