Modified human igf-1r antibodies

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 16/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2535071

The present invention relates to human antibodies, for example those directed to the human IGF-1 receptor (IGF-1R) that are for treatment of cancer, that have one or more selected mutated residues replaced with germline residues. A replaced residue can be a somatic mutation in a framework region.

La présente invention se rapporte à des anticorps humains, par exemple dirigés contre le récepteur IGF-1 (IGF-1R), utilisables dans le traitement des cancers et comportant un ou plusieurs restes mutés choisis et remplacés par des restes germinaux. Un reste remplacé peut être une mutation somatique dans une zone structurelle.

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