Modified human t-pa

Details Modified human t-pa Modified human t-pa

C - Chemistry, Metallurgy

12

N

195/1.22, 167/10

C12N 15/58 (2006.01) A61K 38/49 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) C12N 9/72 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1341458

A tissue plasminogen activator represented by the following amino acid sequence as its primary structure: Image 460 470 AsnMetLeuCysAlaGlyAspThrArgSerGlyGlyProGlnAlaAsnLeuHisAspAla 480 490 CysGlnGlyAspSerGlyGlyProLeuValCysLeuAsnAspGlyArgMetThrLeuVal 500 510 GlyIleIleSerTrpGlyLeuGlyCysGlyGlnLysAspValProGlyValTyrThrLys 520 527 ValThrAsnTyrLeuAspTrpIleArgAspAsnMetArgPro 92 100 wherein R is Ser- or CysTyrGluAspGlnGlyIleSerTyrArgGlyThrTrp 110 120 SerThrAlaGluSerGlyAlaGluCysThrAsnTrpAsnSerSerAlaLeuAlaGlnLys 130 140 ProTyrSerGlyArgArgProAspAlaIleArgLeuGlyLeuGlyAsnHisAsnTyrCys 150 160 ArgAsnProAspArgAspSerLysProTrpCysTyrValPheLysAlaGlyLysTyrSer 170 174 SerGluPheCysSerThrProAlaCysSer- X is -Lys-, -Ile- or bond and Y is -TyrSerGlnProGlnPheArgIle-, -TyrSerGlnProGlnPheAspIle-, -TyrSerGlnProIleProArgSer- or -ThrLeuArgProArgPheLysIle-, and in the above amino acid sequence, Asn184, Asn218 and Asn448 may be glycosylated. This activator has strong activity for converting plasminogen into plasmin that degrades the fibrin network of blood clot to form soluble products and therefore is useful as a thrombolytic agent. There is also described the DNA sequence encoding amino acid sequence of it, a process of producing it and pharmaceutical compositions containing the activator.

573585

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