Modified hydrolyzed vegetable protein microspheres and...

Details Modified hydrolyzed vegetable protein microspheres and... Modified hydrolyzed vegetable protein microspheres and...

C - Chemistry, Metallurgy

07

K

C07K 1/12 (2006.01) A61K 9/16 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2160692

Modified hydrolyzed vegetable protein microspheres and methods for their prepa- ration and use as oral delivery systems for pharmaceutical agents are described. Figure I illustrates levels of glucose detected in rat serum taken from rats orally administered mi- crosphere encapsulated insulin or raw (unen- capsulated) insulin as described in example 4. Figure 2 illustrates rat serum calcium lev- els after oral administration of calcitonin and calcitonin encapsulated in the vegetable pro tein microsphere of the present invention as described in example 5. Figure 3 illustrates an HPLC trace of the hydrolyzed vegetable protein before modification. Figure 4 illus- trates the change in the hydrolyzed vegetable protein after modification with benzene sul- fonyl chloride in an HPLC trace.

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