Modified hydroxypolymer conjugates with bone seeking and...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 51/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2719295

The present inven tion is related to a modified hydroxypolymer conjugate, preferably a dextran-guani-dine-biphosphonate conjugate for treat-ing not only skeletal tumors i.e. bone metastasis, particularly bone metastasis related to hormone refractory prostate cancer HRPC and breast cancer, but also osteoporosis. A method for producing and using said hydroxypolymer conju-gate is also disclosed.

La présente invention concerne un conjugué dhydroxypolymère modifié, de préférence un conjugué de dextrane-guanidine-biphosphonate pour le traitement des tumeurs du squelette, cest-à-dire des métastases osseuses, en particulier des métastases osseuses associées au cancer de la prostate réfractaire aux hormones (HRPC) et au cancer du sein, mais également de lostéoporose. La présente invention concerne également un procédé de production et dutilisation dudit conjugué dhydroxypolymère.

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