Modified influenza virus

Details Modified influenza virus Modified influenza virus

A - Human Necessities

61

K

A61K 39/145 (2006.01) C07K 14/11 (2006.01)

Patent

CA 2705444

The present invention provides an influenza B virus M gene with a modification of at least one nucleotide proximate to the N-terminus of the M gene, more specifically at any one of nucleotide positions 265 to 294 of the M gene as well as an influenza B virus comprising said modified M gene. Further, its use for the preparation of a vaccine and methods for preparing said modified influenza virus are disclosed.

La présente invention concerne un gène M du virus influenza B avec une modification d'au moins un nucléotide à proximité de l'extrémité N-terminale du gène M, plus spécifiquement à l'une quelconque des positions de nucléotides 265 à 294 du gène M ainsi qu'un virus influenza B comprenant ledit gène M modifié. La présente invention concerne en outre son utilisation pour la préparation d'un vaccin et des procédés de préparation dudit virus influenza modifié.

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