C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/53 (2006.01) C07K 16/40 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/04 (2006.01) C12Q 1/32 (2006.01) C30B 29/58 (2006.01)
Patent
CA 2408921
The present invention provides isolated modified inosine 5'-monophosphate dehydrogenase (IMPDH) polypeptides. These modified IMPDH polypeptides comprise a substitute oligo-peptide that replaces the subdomain region. The modified polypeptides of the invention bind to an inhibitor, such as MPA, and/or exhibit functional activity of wild-type IMPDH holo-enzyme.
La présente invention concerne des polypeptides IMPDH, en l'occurrence des 5'-monophosphate déshydrogénase inosine, modifiés, qui ont été isolés. Ces IMPDH modifiés comprennent un oligo-peptide de substitution qui remplace la région de sous-domaine. Les polypeptides modifiés de l'invention se lient à un inhibiteur tel que le MPA, et/ou font preuve d'une activité fonctionnelle de holo-enzyme d'IMPDH de type sauvage.
Einspahr Howard M.
Hollenbaugh Diane L.
Kish Kevin
Krystek Stanley R.
Mouravieff Julie E.
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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